The Jefferson County Scenic Byway is a combination of a greenway, a recreation trail and an area of historic interest. The 15 mile route follows Ohio 150 from Rayland on the east to US 250 on the west and has a southern extension on Ohio 647 from Mount Pleasant to the Belmont County line. 

Of particular historic interest is the village of Mount Pleasant, which was heavily involved with the underground railroad and the anti-slavery activities in the 19th century. The village contains a National Historic District which includes the Friends (Quakers) Yearly Meeting House, built in 1814, and the Free Labor Store, which refused to sell products made by slave labor.