The nearly 60-mile route begins on the north side of the Maumee River in the City of Defiance at the intersection of State Route 66 and State Route 424. The byway follows State Route 424 eastward through Napoleon to the US 6 crossing of the Maumee River. At this location the route stops on the north side until it resumes again just west of the City of Waterville on River Road to the City of Maumee. River Road is identified as Broadway Street in Maumee. The byway continues on Broadway Street eastward to the site of the former British Ft. Miamis, now a city park, where it ends. On the south side of the Maumee, the byways starts at Napoleon on State Route 110 and continues on State Route 65 through the historic towns of Grand Rapids, Perrysburg and Rossford,ending at I-75.