Ohio River Scenic Byway

Spanning 14 counties in southern Ohio, this byway encompasses the entire length of the Ohio River in Ohio, 452 miles. Starting at US 50 at the Indiana border, this route follows US 52, SR 7, SR 124, SR 338, and SR 39 to East Liverpool. The Ohio River Scenic Byway is also in Indiana and Illinois, and is also designated a national Scenic Byway.

The byway swells and curves as it plays hide and seek with the Ohio River. The hills were once covered with grapevines, an extension of the industry began in Cincinnati. The towns along here were almost all part of the Underground Railroad stations that helped transport slaves to freedom in Canada.